I recently had the fortune to have a review copy of the Catalyst Framework for WordPress.
Unlike the framework I have used in the past (this site uses Genesis); Catalyst is aimed at I would say the more designer type person. Why I say that is that you get out the box a basic theme but also the ability to customize it in every aspect.
Because you can customize it so much you do need to be able to have the vision and so if wanting to put together a great site easy and quick with little work it may not be the framework for you. But please go check out the review and see if its right for you.